Giants vs. Redskins 2015, Week 3: Ereck Flowers, Robert Ayers won't play

EAST RUTHERFORD, N.J. -- The New York Giants will be without starting left tackle Ereck Flowers (ankle) and starting defensive end Robert Ayers (hamstring) for Thursday's game against the Washington Redskins.

The 0-2 Giants need a victory against the 1-1 Redskins to help erase the sting of blowing back-to-back fourth-quarter leads in their two season-opening losses.

Without Flowers, Justin Pugh will play left tackle and John Jerry will play left guard. Ayers has been the most effective pass rusher on a defensive line that has struggled to rush the passer.

#Giants Offensive Lineup changes: WR: Randle for Cruz LT: Pugh for Flowers LG: Jerry for Pugh #WASvsNYG

— New York Giants (@Giants) September 24, 2015

#Giants Defensive Lineup changes: CB: Hosley for DRC LDT: Jenkins for Kuhn LDE: Wynn for Jenkins RDE: Selvie for Ayers #WASvsNYG

— New York Giants (@Giants) September 24, 2015

Inactives

WR Victor Cruz (calf), CB Dominique Rodgers-Cromartie, DT Markus Kuhn, DE Owamagbe Odighizuwa and tight end Jerome Cunningham (knee), OT Ereck Flowers and DE Robert Ayers (hamstring) are all out with injuries.

Here is Washington's inactive list:

#WASvsNYG game inactives. pic.twitter.com/rfhwGqKe0e

— Washington Redskins (@Redskins) September 24, 2015

Game Details

What: Giants vs. Redskins

Date: Thursday, Sept. 24

Game time: 8:25 p.m. ET

Where: MetLife Stadium East Rutherford, N.J.

TV: CBS/NFL Network

Announcers: Jim Nantz, Phil Simms, Tracy Wolfson

Giants Radio Network: WFAN 660 AM, 101.9 FM in Tri-State area

Announcers: Bob Papa, Carl Banks, Howard Cross

Local radio affiliates:

Spanish radio broadcast: WADO 1280-AM (Nestor Rosario, Frances Adames)

National radio: Westwood One -- Ian Eagle, Boomer Esiason; SIRIUS -- 83 (Was.), 93 (NYG); XM -- 225 (Was.), 226 (NYG)

Odds: Giants -4

Live stream: NFL Game Pass