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Rex Ryan: LeSean McCoy, Sammy Watkins probably out vs. Giants

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Shady has a hamstring issue that might keep him out of action.

LeSean McCoy
LeSean McCoy
Steve Mitchell-USA TODAY Sports

UPDATED: 2:51 P.M. ET:

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The Buffalo Bills could be without at least one of their two major offensive weapons on Sunday against the New York Giants, with running back LeSean McCoy and wide receiver Sammy Watkins both in doubt right now, according to Bills coach Rex Ryan.

McCoy, of course, was a Giants nemesis during his time with the Philadelphia Eagles. McCoy has 1,036 yards on 199 carries (5.21 yards per carry) in 12 games against the Giants. He has five 100+ yard rushing games against New York

The Bills, though, have fifth-round pick Karlos Williams averaging 7.8 yards per carry (24 rushes, 186 yards).

Watkins has seven catches for 99 yards in three games.Watkins is dealing with a calf injury.

Ryan is scheduled to hold a conference call with New York media at some point today. More from the talkative Bills coach when that happens.