The Giants will be short-handed on defense. Linebackers Devon Kennard (hamstring) and Jonathan Casillas (calf) won't play. Defensive ends Robert Ayers (hamstring) and George Selvie (calf) will also not play. That means linebacker Jasper Brinkley will be active for the first time as a Giant. Could it also mean we see some Cooper Taylor in passing situations?
Cunningham, who has been dealing with a knee issue, was probable. His absence from the active roster means the Giants will have only Larry Donnell and Will Tye at tight end.
Lineup changes for the Giants will have Cullen Jenkins at defensive end, Jay Bromley in Jenkins' usual defensive tackle spot and Mark Herzlich in place of Kennard.
Ahmad Brooks (personal) and Vernon Davis (knee) are the key inactives for San Francisco.
WR Victor Cruz (calf), LB Devon Kennard (hamstring), DE Robert Ayers (hamstring), DE George Selvie (calf), LB Jonathan Casillas (calf), TE Jerome Cunningham, OL Bobby Hart
WR DeAndrew White, RB Mike Davis, LB Gerald Hodges, LB Ahmad Brooks, OL Ian Silberman, DT Mike Purcell, TE Vernon Davis
Use this as your first-half open thread.