Thibodeaux, an edge defender, has been sidelined since suffering a sprained MCL on a cut block by tight end Thaddeus Moss of the Cincinnati Bengals in the first preseason game.
Azeez Ojulari, also an edge defender and the Giants’ 2021 leader in sacks with 8.0, will also miss the game. He is inactive due to a calf injury.
Neither Thibodeaux nor Ojulari did much in practice during the week.
Rookie Dane Belton is the third player on the inactive list due to injury. Belton suffered a broken collarbone early in training camp.
Healthy scratches are:
WR Darius Slayton
RB Antonio Williams
CB Justin Layne
OL Tyre Phillips
The Giants have elevated edge defender Quincy Roche and safety Tony Jefferson from the practice squad to add depth for Sunday’s game.
DB Lonnie Johnson
DT Jamarco Jones
DT Naquon Jones
RB Julius Chestnut
OLB Derrek Tuszka