Also out for the Giants will be safety Adrian Colbert, who will miss a third straight game with a shoulder injury.
Wide receiver C.J. Board, who missed last week’s game with a concussion, is questionable.
Without Freeman, Wayne Gallman will carry most of the load for the Giants. Gallman has carried 25 times for 110 yards this season, 4.4 yards per carry.
“We expect all of our running backs at the game to play. Different game plans may have different roles for different guys, but Wayne’s done a good job overall when he’s gotten into the game. He’s taken advantage of some of the situations he’s been put into,” coach Joe Judge said. “We expect him to have a role in every game that we have, along with Devonta (Freeman), along with Dion (Lewis). We have other backs on our roster as well we work with on a daily basis, we work to develop within our system and have them ready as well when they’re needed. But Wayne’s done a good job when we’ve asked him to.”
The Giants have veteran running back Alfred Morris on their practice squad and could add him to their 53-man roster to take Freeman’s spot.
Wide receiver Chris Godwin (finger) will be out for the Buccaneers.