The New York Giants will be without wide receiver C.J. Board (concussion), safety Adrian Colbert (shoulder) and linebacker Tae Crowder (hamstring/placed on IR) Thursday night against the Philadelphia Eagles.
Cornerback Darnay Holmes, who has been handling the slot, is questionable with a neck injury.
Without Holmes and Colbert, the Giants used Logan Ryan in the slot and Julian Love at free safety last Sunday.
For the Eagles, a half-dozen players have been ruled out. They are:
Offensive tackle Jack Driscoll (ankle), tight end Zach Ertz (ankle), defensive tackle Malik Jackson (quad), running back Miles Sanders (knee), wide receiver Alshon Jeffery (foot) and safety K’Von Wallace (shoulder).
Offensive tackle Lane Johnson (ankle), safety Marcus Epps (rib), wide receiver DeSean Jackson (hamstring) were all full participants and are expected to play. Cornerback Avonte Maddox (ankle) and linebacker Duke Riley (rib) were listed as limited.
The 1-5 Giants and 1-4-1 Eagles meet at Lincoln Financial Field in Philadelphia.