The Giants went 75 yards on five plays with the opening kickoff, scoring on a 27-yard Saquon Barkley run. This was the second straight week the Giants scored a touchdown on their opening possession.
It was all downhill for the Giants after that opening drive. The Bills scored touchdowns on their next three possessions, drives of 75, 70 and 98 yards.
The Giants wasted a 60-yard punt return by T.J. Jones which gave them the ball on Buffalo’s 33-yard line with 1:15 left in the half. Two plays later, an eli Manning pass was tipped and intercepted.
Manning went 9-of-19 for 74 yards and an interception in the first half. Barkley ran 9 times for 69 yards and a touchdown.
Aldrick Rosas missed a 48-yard field goal for the Giants.