The Giants fell behind at halftime, 29-10, as the Patriots scored 26 unanswered points in the second quarter.
With Kyle Lauletta quarterbacking the second half the Giants mounted a comeback. A 27-yard Aldrick Rosas field goal, a 27-yard pass to Scott Simonson and a 6-yard run by Wayne Gallman got the Giants within four, 29-25.
Lauletta hit Alonzo Russell with a 14-yard touchdown pass on the game’s final play to give the Giants the victory. That finished a game-winning 15-play, 70-yard drive engineered by Lauletta in the final 2:16.
Lauletta finished 22-of-40 for 248 yards and two touchdowns.
Russell finished with five caches for 92 yards and two touchdowns
Alex Tanney went 4-of-12 for 53 yards with a touchdown and two interceptions.
Linebacker B.J. Goodson had an active first half with six tackles, a sack and a quarterback hit.
Paul Perkins, bidding for a spot as a backup to Saquon Barkley, had his best game of the preseason. Perkins carried 11 times for 54 yards, including a 24-yard run. Wayne Gallman had seven carries for 29 yards, including, including a 6-yard touchdown run.
Simonson was carted off in the third quarter with an injury to his left ankle. Wide receiver T.J. Jones was also carted off with an ankle injury. Linebacker Keion Adams (knee), wide receiver Brittan Golden (calf), cornerback Ronald Zamort (ankle), linebacker Nate Stupar (concussion).
Several of those injuries could impact the construction of the 53-man roster.
Quick night for Danny Dimes
Daniel Jones got the start Thursday, and the preseason starting quarterback treatment. Jones went 4-for-4 for 47 yards including a 23-yard throw to Golden Tate, but the Giants turned the ball over on downs at the New England 13-yard line.
Jones finished the preseason 29-of-34 (85.3 percent) for 416 yards, two touchdowns and no interceptions.
Real football! The Giants open their regular season in Arlington vs. the Dallas Cowboys on Sept. 8. Game time is 4:25 p.m. ET.