San Francisco 49ers (7-0) at Arizona Cardinals (3-4-1)
Game time: 8:20 p.m. ET
Where: State Farm Stadium
Referee: Brad Rodgers
TV Channel: Fox, NFL Network
Live Stream: Twitch, Amazon Prime, NFL.com
Announcers: Joe Buck, Troy Aikman, Erin Andrews, Kristina Pink
Radio: Westwood One: Kevin Kugler, Matt Millen SIRIUS: 81 (SF), 83 (Ari) | XM: 225 (SF), 226 (Ari)
Odds: 49ers -10.5
The 49ers are one of the most surprising stories of 2019, after being one of two remaining undefeated teams. They’re currently riding on the shoulders of one of the hottest defenses in the NFL. Their unit features a plethora of elite playmakers, but the biggest name right now is rookie Nick Bosa, who is terrorizing opposing offenses. The 49ers are coming off an explosive 51-13 win over Carolina.
Arizona is also a polarizing team in 2019 because of their rookie head coach and quarterback. Up and down weeks this season have halted the Cardinals progress to getting over .500. Kliff Kingsbury’s air raid offense led by Kyler Murray is relatively productive this year. They also added an additional weapon after trading for Dolphins running back Kenyan Drake.