Elliot Harrison of NFL.com is picking the 49ers:
To think that there was a time when this was the premier matchup in the NFL. This one is an excit- ... No, I can't do it. Can't sell this baby unless Jimmy Garoppolo plays -- then we have something. Tell you what, though: One of the most anticipated prime-time games of my lifetime was Giants at 49ers, Monday Night Football, 1990. Both teams had just lost their first game of the season in the previous week, entering the marquee matchup with identical 10-1 records. The Niners would win a defensive struggle, 7-3, with Phil Simms and Ronnie Lott exchanging heated words afterward. Both teams were so good that they met a month later in the NFC Championship Game at Candlestick. Big Blue -- with Bill Parcells, Bill Belichick and Tom Coughlin -- moved on to Super Bowl XXV. That was a loaded 49ers team, too. These teams aren't loaded. But Eli Manning is about to tie his brother, Derrick Brooks and Ronde Barber for the fourth-most consecutive starts in NFL history (208).
Pro Football Talk’s two analysts are split.
At CBS Sports, five of eight analysts are picking the Giants.
The FOX Sports simulator has the Giants winning 58.5 percent of the time.
At ESPN, only three of 11 analysts are picking the Giants to win.
At Sports Illustrated, the six analysts are split, 3-3.
At USA Today, four of five analysts are picking the 49ers.
FiveThirtyEight gives the Giants a 62 percent chance of winning.