Eli Manning: Sit him.
Unless you are in a deeper league or in a league that starts two quarterbacks, there are probably better options this week. While I'll still maintain the idea that Manning will finish as a top 10 fantasy quarterback, the offense has yet to click. It took some time early last year for everything to heat up and the Atlanta Falcons have a very solid secondary. While I wouldn't doubt that Eli will have a solid game, there are QBs with more upside this week. Carson Palmer for example is available to up to 50 percent of fantasy leagues and should be a solid bet to be a top QB against a porous Chicago Bears defense.
Odell Beckham Jr: Start him.
There is a saying that you always start your studs. Odell Beckham is most likely your top receiver and should under no circumstance be benched if healthy. Heck even if he has one foot, he's a must start.
Reuben Randle: Sit him.
Randle has irked many Giants fans due to his inconsistency but when he's been the second option to Beckham, Randle has posted great numbers. The touchdowns haven't been there but with defenses keying on Beckham, the yardage has been solid as he was on a 1,200-yard pace if we only look at the games he started with Beckham. That being said, Randle didn't do anything at all against the Dallas Cowboys and his training camp was plagued with his knee tendinitis. While he should be owned for depth purposes, you probably have a better option than the inconsistent Randle. When he heats up, though, he can post WR2 numbers.
Larry Donnell: Start him.
At this point if you don't have Rob Gronkowski, Jimmy Graham, Travis Kelce or Greg Olsen you're looking for anyone to play tight end. Both the Giants tight ends were open often against the Cowboys which led to targets but against the Falcons, Daniel Fells is already confirmed as out. The tight end is a favorite target for Manning in the end zone which makes Donnell a solid start this week.
Rashad Jennings: Start him.
Running backs are a rare commodity which makes every lead back a must own player in fantasy. Despite being apart of a very solid running back group, Jennings is the clear lead back with 13 carries compared to six carries for Andre Williams and only two carries for Shane Vereen. Even though Williams is known for his power, Jennings is still the goal line back as he scored a touchdown against the Cowboys and was in prime position for another one before he was told to "not score." You likely don't have a lot of better options at running back and even though he's not highly regarded by the fantasy analysts, you can do a lot worse than Rashad Jennings.
Shane Vereen: Start him (for PPR).
He's only viable for PPR and even then only he's only for your flex position. He was quiet against the Cowboys, especially with only two carries but his receptions and yardage was able to net him a solid 10 points against the Cowboys. Tom Coughlin expressed interest in getting Vereen more involved with the offense but at the bare minimum like against the Cowboys, he should have a solid floor in PPR. In standard, he might not honestly be worth a roster spot.