Houston Texans (6-5) at Buffalo Bills (5-6)
The AFC South isn't looking as terrible anymore as both the Texans and Indianapolis Colts have gotten over the .500 mark for a tie in the division lead. Houston will look to keep rolling when they take on Rex Ryan and the Bills. This will be an exciting battle of former Clemson wideouts between Texans receiver DeAndre Hopkins and Bills receiver Sammy Watkins, both of whom have been starting to break out lately.
San Francisco 49ers (3-8) at Chicago Bears (5-6)
The Bears have played better of late, especially with a great Thanksgiving win over the Green Bay Packers, but are still below the .500 mark. The 49ers played well but lost a close game last week to the Arizona Cardinals. Blaine Gabbert passed for a career-high 318 yards last week in the 49ers defeat.
Cincinnati Bengals (9-2) at Cleveland Browns (2-9)
Browns fans are already wondering if it's draft season yet.
Baltimore Ravens (4-7) at Miami Dolphins (4-7)
The Ravens have been hampered by injuries but found a way to beat Cleveland on Monday Night Football. Rookie running back Javorius Allen has 200 scrimmage yards in his past two games for Baltimore. For Miami, Ryan Tannehill needs just nine passing yards to tie Dan Marino as the only Dolphins quarterbacks with at least four 3,000-yard seasons.
Seattle Seahawks (6-5) at Minnesota Vikings (8-3)
The Seahawks are currently slotted for the Wild Card. while the Vikings are a half-game up on the Packers in the division after Green Bay beat Detroit on Thursday Night Football. Adrian Peterson has been a bell cow for the Vikings and has had a resurgent comeback season, being right at the top of the NFL in rushing yards. As for the Seahawks, they'll be without star tight end Jimmy Graham, who suffered a season-ending patellar injury, as well as top running back Marshawn Lynch.
Arizona Cardinals (9-2) at St. Louis Rams (4-7)
Don't count the Rams out in this one, as they've played very well against the NFC West and are one of the two teams that defeated Arizona earlier in the season. However, Arizona is playing for home-field advantage in the playoffs and should come out with high intensity.
Atlanta Falcons (6-5) at Tampa Bay Buccaneers (5-6)
Both teams are fighting for playoff hopes, so this has the makings of a grudge match. Tampa Bay defeated Atlanta earlier in the season and is right on their heels in the NFC Wild Card race.
Jacksonville Jaguars (4-7) at Tennessee Titans (2-9)
Blake Bortles needs just two passing touchdowns (22) to eclipse David Garrard (23 in 2010) for the most passing touchdowns in a single season in Jaguars franchise history, so that's cool. Jaguars running back TJ Yeldon leads all AFC rookies in rushing yards, while wide receivers Allen Robinson and Allen Hurns have both provided sparks. The Jaguars have pieces on offense, but when will they put it all together? The Titans defense, which is better against the run, should provide a good test.
Kansas City Chiefs (6-5) at Oakland Raiders (5-6)
Don't look now, but the Kansas City Chiefs are in Wild Card contention. Running backs Charcandrick West and Spencer Ware have impacted the Chiefs' offense tremendously, as well as free agent acquisition Jeremy Maclin. The Chiefs defense is also playing a lot better of late, led by linebackers Justin Houston and Tamba Hali, who has 5.5 sacks in the past five games.
Denver Broncos (9-2) at San Diego Chargers (3-8)
The Broncos are riding the hot hand of quarterback Brock Osweiler. Can he keep the momentum up on the road against a struggling Chargers team?
Philadelphia Eagles (4-7) at New England Patriots (10-1)
Tom Brady and the Patriots were dethroned from their perfect porch last weekend and are banged up as badly as ever. It still doesn't look good for the Eagles' subpar secondary.
Carolina Panthers (11-0) at New Orleans Saints (4-7)
The winning streak started here last year for the Panthers, but can the Saints now end it?
Indianapolis Colts (6-5) at Pittsburgh Steelers (6-5)
This Sunday Night matchup could show out a lot of offensive firepower. Colts running back Frank Gore needs just five scrimmage yards to surpass Hall of Fame running back Jim Brown for 23rd-most all-time. Indianapolis wideout Andre Johnson needs just 85 receiving yards to move into ninth all-time in receiving yards.