Buffalo Bills (3-3) at Jacksonville Jaguars (1-5) (London)
The Buffalo Bills come into this game without receivers Sammy Watkins, Percy Harvin and Marquise Goodwin, as well as starting quarterback Tyrod Taylor. However, E.J. Manuel did have success in his only meeting against the Jaguars, passing for two touchdowns and running in another. For the Jaguars, Blake Bortles has been hot lately, as he aims for his third game in a row passing for more than 300 yards and three touchdowns. In his first game as a member of Jacksonville last week, tight end Julius Thomas had 78 receiving yards and a touchdown. This game will be streamed online on Yahoo.
New York Jets (4-1) at New England Patriots (5-0)
Jets cornerback Darrelle Revis will face his former team, who he won a Super Bowl ring with last season. The Jets are in position to tie the Patriots at the top of the AFC East, but it won't be an easy task. New England has won eight of its last nine contests against New York. Former Giants punter Steve Weatherford will suit up for the Jets in this one.
Minnesota Vikings (3-2) at Detroit Lions (1-5)
Tampa Bay Buccaneers (2-3) at Washington Redskins (2-4)
First overall pick James Winston has passed for more than 200 yards and a touchdown in all five of his starts this season while leading the Tampa Bay offense. His running backs, Doug Martin and Charles Sims, have been an impact on the offense as well, gaining nearly 300 yards from scrimmage in the team's Week 5 victory over the Jaguars. As for the Redskins, Kirk Cousins is a top five quarterback in the NFC in terms of completions and attempts. Rookie receiver Jamison Crowder leads all NFC rookies with 27 receptions for 244 yards.
New Orleans Saints (2-4) at Indianapolis Colts (3-3)
Both teams have lots of problems, but the quarterback play is what drives both franchises. Drew Brees and Andrew Luck are both starting to get in the groove, each passing for more than 1,000 yards in their last four games. Saints linebacker Hau'oli Kikaha leads all rookies in sacks, with four.
Pittsburgh Steelers (4-2) at Kansas City Chiefs (1-5)
Houston Texans (2-4) at Miami Dolphins (2-3)