Game time: 8:25 p.m. ET
Where: Sports Authority Field at Mile High in Denver, Colo.
TV: CBS/NFL Network
Announcers: Jim Nantz, Phil Simms, Tracy Wolfson
Odds: Broncos -6.5 | Jesse's Pick: Broncos
The Broncos are seeking their fourth straight victory. Quarterback Peyton Manning threw three touchdown passes last week in a 42-17 victory over the San Francisco 49ers, becoming the all-time leader in regular-season touchdown passes. He now has 510, surpassing Brett Favre's previous mark of 508.
The Chargers come off a 23-20 loss last week to the Kansas City Chiefs.