Quarterback Eli Manning was intercepted three times -- twice on screen passes. The Giants fumbled three times, two by David Wilson and one on a botched punt.
The Giants had a chance to win the game late, getting the ball with 3:41 left and trailing, 30-24. Da'Rel Scott -- replacing the benched Wilson -- had a screen pass bounce off his hands that resulted in a game-sealing 49-yard interception return for a touchdown by Cowboys' cornerback Brandon Carr with
Manning finished 27-of-42 for 450 yards with four touchdowns and the three interceptions. Hakeem Nicks (5 catches, 114 yards), Victor Cruz (5 catches, 118 yards, 3 touchdowns) and Rueben Randle (5 catches, 101 yards) all surpassed 100 receiving yards for the Giants.
Dallas quarterback Tony Romo completed 36-of-49 passes for 263 yards with two touchdowns and one interception.
The loss for the Giants is their first in five games at AT&T Stadium.
Prince Amukamara of the Giants left the game in the first half with a concussion.