Manning was injured when he was hit while attempting a pass late in the second quarter. A hobbled Manning threw his 27th interception of the season on the next play, then immediately exited for the locker room. Manning was sacked a career-high 39 times this season. After the game head coach Tom Coughlin said Manning had suffered a high ankle sprain.
Curtis Painter took over at quarterback in the second half.
Hakeem Nicks also saw his season, and possibly his Giants' career come to an end in the first half. Nicks sprained an ankle when he was called for pass interference in the end zone. He ended the season with 56 catches, 896 yards and no touchdowns. Nicks is a free agent, and most experts expect Nicks to depart the Giants.
Will Beatty was carted off early in the third quarter. He ended up with the worst injury of all, a fractured leg.