Game Time: 8:30 p.m. ET
Odds: Colts -1
How will the Texans undrafted free agent quarterback Case Keenum play in only his second career start against the man who was drafted first in his class, Colts quarterback Andrew Luck? Will Colts receivers T.Y. Hilton and Darrius Heyward-Bey be able to step up to help replace the loss of one of the best receivers of this generation in Reggie Wayne? How much will Texans running backs Arian Foster and Ben Tate play coming off of injuries in their last game? And how effective can they be? Will Colts running back Trent Richardson finally prove he was worth the first round draft pick the Colts traded for him? Use this as an Open Thread to discuss the action.