At first glance, it seems like a simple question--who will step into Sash's role for the first four games? However, it has implications for other positions on the roster.
1. It means the Giants will have to start the season with five safeties on the roster. If Sash were able to play, they could start with four, but with Sash suspended, they're not likely to start with only three eligible safeties. They have to add one. There are plenty of willing bodies, that's not the problem. The problem is, they will also certainly start with five CBs, and that makes ten DBs. Normally, they might try to get by with nine DBs, so this makes it much less possible to carry eight linebackers or four running backs or five defensive tackles. In other words, Sash's suspension reduces the chances for Andre Brown, Da'Rell Scott, Spencer Paysinger, Markus Kuhn, among others. One of these playeres, or perhaps someone else, is not going to make the team because of Sash's suspension.
2. The Giants will have to replace Sash with another special teams player. That improves the chances for someone like Dave Douglas over Ramses Barden. I don't know for a fact that Douglas could contribute on special teams, but he certainly seems to have the body and attitude for it. Unlike Barden.
There are probably other subtle consequences of of Sash's suspension, these are just a couple.