Cruz has eight catches for 125 yards already, including a 36-yarder that set up the Giants first touchdown. Manning is 16-of-27 for 181 yards and one touchdown.
San Francisco struck first, stunning the Giants with a 73-yard first quarter touchdown pass from Alex Smith to Vernon Davis.
The Giants tied the game when Manning capped a 10-play, 69-yard drive in the second quarter with a six-yard pass to Bear Pascoe. Lawrence Tynes 31-yard field goal with five seconds left in the first half put the Giants into the lead for the first time.
The Giants have dominated time of possession, 18:03 to 11:57 and lead in overall yardage, 199-144. The single big play by the 49ers is the only real movement San Francisco has gotten on offense, although Frank Gore does have 46 yards rushing on nine carries.